海玲,女,1993年2月出生,高聘副研究员。从事生物信息学方向,已参与十余个合作研究项目,其中一项以第一作者身份在Nature Communications发表学术论文,研究成果获得德国癌症研究中心(DKFZ)、德国国家肿瘤疾病中心(NCT)、德国癌症联盟(DKTK)、海德堡大学医院(UKHD)等官网报道。本人获得了海德堡大学的最优等(Summa Cum Laude)博士学位。
【联系方式】
邮箱:hailing@hainanu.edu.cn
【研究方向】
多学科交叉,多组学数据分析,单细胞测序数据分析,大数据挖掘,人工智能,机器学习,以及数据分析工具开发。
【学习经历】
2018年 至 2024年,海德堡大学/德国癌症研究中心(DKFZ),生物信息学,博士
2015年 至 2018年,浙江大学,生物信息学,硕士
2010年 至 2014年,东南大学,自动化,学士
【工作经历】
2024年 至 今,永利集团,永利集团88304,高聘副研究员
2021年 至 2024年,海德堡大学医院/德国癌症研究中心(DKFZ),博士后
【学术论文】
Hai, L.†, Hoffmann, D.C.†, …, Kessler, T.*, 2024. A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1, Nature Communications, 15(1):968. https://doi.org/10.1038/s41467-024-45067-8. (SCI,中科院大类一区,共一排1,IF5=17)
海玲;陈新;基于病例转录组特征的精准用药搜索系统,《基因组学与应用生物学》,2018 (02) 637-642(CSCD来源期刊、北京大学图书馆《中文核心期刊要目总览》期刊)
陈新;海玲;陈鹏程,一种基于基因功能关联网络发现慢性病机制及其预警干预策略的方法,2018-12-21,中国,ZL201610442551.2 (授权专利)
Hausmann, D., Hoffmann, D.C., Venkataramani, V., Jung, E., Horschitz, S., Tetzlaff, S.K., Jabali, A., Hai, L., …,Winkler, F. * 2023. Autonomous rhythmic activity in glioma networks drives brain tumour growth. Nature 613 (7942): 179-186. https://doi.org/10.1038/s41586-022-05520-4. (SCI,中科院大类一区, IF5=60.9)
Venkataramani, V. *, Yang, Y., Schubert, M.C., Reyhan, E., Tetzlaff, S.K., Wissmann, N., Botz, M., Soyka, S.J., Beretta, C.A., Pramatarov, R.L., Fankhauser, L., Garofano, L., Freudenberg, A., Wagner, J., Tanev, D.I., Ratliff, M., Xie, R., Kessler, T., Hoffmann, D.C., Hai, L., …, Kuner, T. *,Winkler, F.* 2022. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell 185 (16): 2899-2917 e31. https://doi.org/10.1016/j.cell.2022.06.054. (SCI,中科院大类一区, IF5=57.5)
Huppertz, M-C. †, Wilhelm, J. †, Grenier; V., Schneider; M.W., Falt, T., Poryberg, N., Hausmann, D., Hoffmann, D.C., Hai, L., …, Hiblot, J. *, Johnsson K. *. 2024. Recording Physiological History of Cells With Chemical Labeling. Science. 383(6685):890-897. https://doi.org/10.1126/science.adg0812. (SCI,中科院大类一区, IF5=54.5)
Gengenbacher, N. †, Singhal, M. †, Mogler, C. , Hai, L., …, Augustin, H.G. * 2021. Timed Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis. Cancer Discov 11 (2): 424-445. https://doi.org/10.1158/2159-8290.CD-20-0122. (SCI,中科院大类一区, IF5=34.7)
Singhal, M. †, Gengenbacher, N. †, Abdul Pari, A.A. †, Kamiyama, M., Hai, L., …,Augustin, H.G. 2021. Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci Transl Med 13 (609): eabe6805. https://doi.org/10.1126/scitranslmed.abe6805. (SCI,中科院大类一区, IF5=19)
Kaulen, L.D. †*, Denisova, E. †, Hinz, F., Hai, L., …, Sahm F. *, Wick, W. * 2023. Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas. Acta Neuropathol 146 (3): 499-514. https://doi.org/10.1007/s00401-023-02613-w. (SCI,中科院大类一区, IF5=16.2)
Xie, R., Kessler, T., Grosch, J., Hai, L., …, Winkler, F*. 2021. Tumor cell network integration in glioma represents a stemness feature. Neuro Oncol 23 (5): 757-769. https://doi.org/10.1093/neuonc/noaa275. (SCI,中科院大类一区, IF5=15.1)
Alhalabi, O.T., Fletcher, M.N.C., Hielscher, T., Kessler, T., Lokumcu, T., Baumgartner, U., Wittmann, E., Schlue, S., Gottmann, M., Rahman, S., Hai, L., …, Phillips, E. *,Goidts, V. * 2022. A novel patient stratification strategy to enhance the therapeutic efficacy of dasatinib in glioblastoma. Neuro Oncol 24 (1): 39-51. https://doi.org/10.1093/neuonc/noab158. (SCI,中科院大类一区, IF5=15.1)
Ratliff, M., Karimian-Jazi, K., Hoffmann, D.C., Rauschenbach, L., Simon, M., Hai, L., …, Winkler, F.* 2023. Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression. Neuro Oncol. https://doi.org/10.1093/neuonc/noad109. (SCI,中科院大类一区, IF5=15.1)
Kessler, T. *, Schrimpf, D., Doerner, L., Hai, L., …., Wick, A. 2023. Prognostic markers of DNA methylation and NGS sequencing in progressive glioblastoma from the EORTC-26101 trial. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-23-0926. (SCI,中科院大类一区, IF5=12.5)
Yao, H., Wang, X., Chen, P., Hai, L., …, Chen, X.* 2018. Predicted Arabidopsis Interactome Resource and Gene Set Linkage Analysis: A Transcriptomic Analysis Resource. Plant Physiol 177(1): 422–433. https://doi.org/10.1104/pp.18.00144 (SCI,中科院大类一区, IF5=8.7)
Kessler, T. *, Berberich, A., Casalini, B., Druschler, K., Ostermann, H., Dormann, A., Walter, S., Hai, L., …, Wick, A. 2020. Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma. Neurooncol Adv 2 (1): vdz060. https://doi.org/10.1093/noajnl/vdz060. (SCI,中科院暂未收录, IF5=3.6)